Natalizumab es un anticuerpo monoclonal que actúa sobre un grupo de moléculas denominadas integrinas.
Definición de Natalizumab más completo

Dr Doug Brown, Head of Biomedical Research at theMS Society, said, "Natalizumab is a licensed treatment for MS in the UK and we have known for some time that it reduces relapse rates and progression of disability in people with relapsing remitting MS; it’s nice to see these findings confirmed in this review.”
HONOLULU (EGMN) – Results of five diverse studies on the risk of progressive multifocal leukoencephalopathy when using natalizumab to treat multiple sclerosis could change the way clinicians decide how to manage these patients.
The U.S. Food and Drug Administration has identified a new risk factor for progressive multifocal leukoencephalopathy, a life-threatening brain infection associated with the use of natalizumab, an immunomodulatory agent used to treat multiple sclerosis and Crohn’s disease.
[04-22-2011] The U.S. Food and Drug Administration (FDA) continues to evaluate the risk of progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection, associated with use of Tysabri (natalizumab) for the treatment of multiple sclerosis (MS) and Crohn's disease.
In uno studio condotto da un gruppo di ricercatori di diversi stati, e pubblicato sulla rivista Archives of Neurology, alcuni dei pazienti che avevano sospeso il trattamento con natalizumab hanno sviluppato la Sindrome Infiammatoria da Ricostituzione Immunitaria (IRIS).
HONOLULU (EGMN) –Patients taking natalizumab showed similar or only slightly delayed humoral immune responses following vaccinations, compared with patients not taking the drug for relapsing-remitting multiple sclerosis in a multicenter, randomized, open-label study.
It is estimated about 8,000 to 10,000 children (those who are up to the age of 18) have multiple sclerosis (MS), with 5% of the total number being younger than
Tysabri was withdrawn in February 2005 after two deaths because of PML . The Biogen Idec announced that no new cases of a PML (progressive multifocal leukoencephalopathy ) have been reported among patients taking Biogen Idec's multiple sclerosis drug Tysabri, since the FDA allowed it back into the market.
The newest research is showing that, caught early, PML doesn't have to be as much of a worry as it has been. "We used to think PML was always fatal, but now we are learning that it might not always be," says Kate Weiss, a spokesperson for Biogen, Inc., the makers of natalizumab.
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